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Microwave-Promoted Selective Regeneration of Carbonyl Compounds from Oximes Using N-Bromosaccharin

Ardeshir Khazaei*, Abbas Amini Manesh

*Department of Chemistry, Faculty of Sciences, Bu-Ali Sina University, P. O. Box 65178-4111, Hamadan, Iran, Email:

A. Khazaei, A. A. Manesh, Synthesis, 2004, 1739-1740.

DOI: 10.1055/s-2004-829163


N-bromosaccharin is an efficient reagent for the oxidative cleavage of oximes to the corresponding aldehydes and ketones under microwave irradiation in a domestic microwave oven. This procedure features short reaction times, high chemoselectivity (no over-oxidation), easy work-up and high yields.

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Key Words

aldoxime, ketoxime, aldehydes, ketones, microwave, N-bromosaccharin

ID: J66-Y2004-2180