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Room temperature ionic liquid promoted improved and rapid synthesis of 2,4,5-triaryl imidazoles from aryl aldehydes and 1,2-diketones or α-hydroxyketone

Shapi A. Siddiqui, Umesh C. Narkhede, Sanjay S. Palimkar, Thomas Daniel, Rajgopal J. Lahoti and Kumar V. Srinivasan*

*Division of Organic Chemistry; Technology, National Chemical Laboratory, Dr. Homi Bhabha Road, Pune 411 008, India, Email:

S. A. Siddiqui, U. C. Narkhede, S. S. Palimkar, T. Daniel, R. J. Lahoti, K. V. Srinivasan, Tetrahedron, 2005, 61, 3539-3546.

DOI: 10.1016/j.tet.2005.01.116

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An improved and rapid one-pot synthesis of 2,4,5-triaryl imidazoles in a room temperature ionic liquid does not need any added catalyst. This one-pot methodology offers excellent isolated yields, simple work up procedures and efficient recovery and recycling of the ionic liquid.

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Key Words

imidazoles, ionic liquids, ammonium acetate, benzaldehydes, 1,2-diketones, α-hydroxyketones

ID: J72-Y2005-2890