Synthesis of (Z)-1-bromo-1-alkenes and terminal alkynes from anti-2,3-dibromoalkanoic acids by microwave-induced reaction
Chunxiang Kuang*, Qing Yang, Hisanori Senboku and Masao Tokuda
*Department of Materials Chemistry, Graduate School of Engineering, Osaka University, Suita 565-0871, Japan, Email: kuangch.wani.osaka-u.ac.jp
C. Kuang, Q. Yang, H. Senboku, M. Tokuda, Tetrahedron, 2005, 61, 4043-4052.
DOI: 10.1016/j.tet.2005.02.043
see article for more examples
Abstract
(Z)-1-Bromo-1-alkenes were stereoselectively efficiently prepared in high yields by microwave irradiation of the corresponding anti-2,3-dibromoalkanoic acids in DMF using Et3N as base. Microwave-assisted one-pot syntheses of terminal alkynes and enynes from 2,3-dibromoalkanoic acids were also developed.
see article for more reactions
see article for more examples
C. Kuang, H. Senboku, M. Tokuda, Tetrahedron, 2005, 61, 637-642.
Key Words
(Z)-1-Bromo-1-alkenes, anti-2,3-Dibromoalkanoic acids, Terminal alkynes, Microwave irradiation
ID: J72-Y2005-2910