Silicaphosphine (Silphos): a filterable reagent for the conversion of alcohols and thiols to alkyl bromides and iodides
Nasser Iranpoor*, Habib Firouzabadi*, Arezu Jamalian and Foad Kazemi
*Department of Chemistry, College of Sciences, Shiraz University, Shiraz 71454, Iran, Email: iranpoorchem.susc.ac.ir, firouzabadichem.susc.ac.ir
N. Iranpoor, H. Firouzabadi, A. Jamalian, F. Kazemi, Tetrahedron, 2005, 61, 5699-5704.
Silicaphosphine (Silphos), [P(Cl)3−n(SiO2)n] is a new heterogeneous reagent that converts alcohols and thiols to their corresponding bromides and iodides in the presence of molecular halogen in refluxing CH3CN in high to quantitative yields. Separation of the Silphos oxide byproduct can be achieved by a simple filtration.
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Silphos, Silicaphosphine, Alcohol, Thiol, Alkyl bromides, Benzyl bromides, Alkyl iodides, Benzyl iodides