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Domino Primary Alcohol Oxidation-Wittig Reaction: Total Synthesis of ABT-418 and (E)-4-Oxonon-2-enoic Acid

Jyoti Shet, Vidya Desai, Santosh Tilve*

*Department of Chemistry, Goa University, Taleigao Plateau, Goa 403 206, India, Email:

J. Shet, V. Desai, S. Tilve, Synthesis, 2004, 1859-1863.

DOI: 10.1055/s-2004-829123

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A domino oxidation of primary alcohols gives α,β-unsaturated compounds using the combination of PCC-NaOAc and stabilized Wittig reagents.

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Key Words

primary alcohols, oxidation, pyridinium chlorochromate, olefination, enones, α,β-unsaturated esters, domino reaction

ID: J66-Y2004-2240