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Highly Efficient Double-Activation Catalysts for the Synthesis of Ketone Cyanohydrins

Fu-Xue Chen, Xiaohua Liu, Bo Qin, Hui Zhou, Xiaoming Feng*, Guolin Zhang

*Key Laboratory of Green Chemistry & Technology (Sichuan University), Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, P. R. China, Email:

F.-X. Chen, X. Liu, B. Qin, H. Zhou, X. Feng, G. Zhang, Synthesis, 2004, 2266-2272.

DOI: 10.1055/s-2004-831167


Tertiary cyanohydrin trimethylsilyl ethers were synthesized in excellent yields by using a catalytic-amount of a salen-Al complex and an N-oxide without solvent at ambient temperature. Transition states for double-activation catalysis were proposed.

see article for more examples

A mild and efficient cyanosilylation of ketones catalyzed by a Lewis acid-Lewis base bifunctional catalyst

Y. Shen, X. Feng, Y. Li, G. Zhang, Y. Jiang, Tetrahedron, 2003, 59, 5667-6675.

Key Words

addition reactions, aluminum, ketones, Schiff bases, nitriles, cyanohydrins

ID: J66-Y2004-2320