IBX/n-Bu₄NBr/CH₂Cl₂-H₂O: a new mild system for selective oxidation of secondary alcohols

Chutima Kuhakarn*, Krisada Kittigowittana, Manat Pohmakotr and Vichai Reutrakul

*Department of Chemistry, Faculty of Science, Mahidol University, Rama 6 Road, Bangkok 10400, Thailand, Email: scckkmahidol.ac.th

C. Kuhakarn, K. Kittigowittana, M. Pohmakotr, V. Reutrakul, Tetrahedron, 2005, 61, 8995-9000.

DOI: 10.1016/j.tet.2005.07.051

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Abstract

A chemoselective oxidation of secondary alcohols with IBX/n-Bu₄NBr in CH₂Cl₂-H₂O gave ketones in good yields and allowed the oxidation of secondary hydroxyl group even in the presence of primary hydroxyl groups.

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Key Words

Selective oxidation, Ketones, IBX oxidation

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ID: J72-Y2005-3060