General synthesis of (1-substituted-1H-1,2,3-triazol-4-ylmethyl)-dialkylamines via a copper(I)-catalyzed three-component reaction in water

Ze-Yi Yan, Ya-Bin Zhao, Ming-Jin Fan, Wei-Min Liu and Yong-Min Liang*

*State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, People's Republic of China, Email: liangymlzu.edu.cn

Z.-Y. Yan, Y.-B. Zhao, M.-J. Fan, W.-M. Liu, Y.-M. Liang, Tetrahedron, 2005, 61, 9331-9337.

DOI: 10.1016/j.tet.2005.07.060

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Abstract

A copper(I)-catalyzed three-component reaction of amines, propargyl halides and azides forms 1-substituted-1H-1,2,3-triazol-4-ylmethyl)-dialkylamines in water. Synthetic advantages are high atom economy, low environmental impact, atmospheric oxygen, wide substrate scope, mild reaction condition and good yields.

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Key Words

Copper(I)-catalyzed, Triazoles, Multicomponent Reactions, Water, Click Chemistry

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ID: J72-Y2005-3080