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Use of tetrahydropyrimidinium salts for highly efficient palladium-catalyzed cross-coupling reactions of aryl bromides and chlorides

Ismail Özdemir*, Serpil Demir and Bekir Çetinkaya

*Department of Chemistry, Inönü Universityt, 44280 Malatya, Turkey, Email:

I. Özdemir, S. Demir, B. Çetinkaya, Tetrahedron, 2005, 61, 9791-9798.

DOI: 10.1016/j.tet.2005.06.064

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Sterically demanding 1,3-dialkyl-3,4,5,6-tetrahydropyrimidinium salts as NHC precursors in combination with palladium acetate provided active catalysts for the cross-coupling of aryl chlorides and bromides under mild conditions. The catalytic system was applied to the Heck, Suzuki and benzaldehyde coupling reactions.

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Key Words

Suzuki Coupling, Heck Reaction, Biaryl Synthesis

ID: J72-Y2005-3090