A palladium catalyzed efficient synthesis of γ-methylene-α,β-unsaturated γ-lactones via cyclization of 3,4-alkadienoic acids
Shengming Ma* and Fei Yu
*State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, People's Republic of China, Email: masmmail.sioc.ac.cn
S. Ma, F. Yu, Tetrahedron, 2005, 61, 9896-9901.
γ-Methylene-α,β-unsaturated γ-lactones were efficiently synthesized by a Pd-catalyzed cyclization of 3,4-alkadienoic acids. The use of a N2 atmosphere ensures a high purity of the products.
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S. Li, B. Miao, W. Yuan, S. Ma, Org. Lett., 2013, 15, 977-979.
C. Fu, S. Ma, Eur. J. Org. Chem., 2005, 3942-3945.
3,4-Alkadienoic acids, Palladium, CuCl2, Cyclization, Butenolides