Iridium-catalyzed enantioselective Pauson-Khand-type reaction of 1,6-enynes
Takanori Shibata*, Natsuko Toshida, Mitsunori Yamasaki, Shunsuke Maekawa and Kentaro Takagi
*Department of Chemistry, School of Science and Engineering, Waseda University, Shinjuku, Tokyo 169-8555, Japan, Email: tshibatawaseda.jp
T. Shibata, N. Toshida, M. Yamasaki, S. Maekawa, K. Takagi, Tetrahedron, 2005, 61, 9974-9979.
A chiral iridium diphosphine complex catalyzes an enantioselective intramolecular Pauson-Khand-type reaction to give various chiral bicyclic cyclopentenones. A low partial pressure of carbon monoxide is important to achieve excellent enantioselectivity.
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