1,3-Dibromo-5,5-Dimethylhydantoin [DBDMH] as an Efficient and Selective Agent for the Oxidation of Thiols to Disulfides in Solution or under Solvent-Free Conditions
Ardeshir Khazaei*, Mohammad Ali Zolfigol, Amin Rostami
*Department of Chemistry, Faculty of Science, Bu-Ali Sina University, P.O.
Box 65174-4119, Hamedan, Iran, Email: a_khazaei
basu.ac.ir
A. Khazaei, M. A. Zolfigol, A. Rostami, Synthesis, 2004, 2959-2961.
DOI: 10.1055/s-2004-834919
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Abstract
A mild and efficient oxidation of various thiols affords the corresponding disulfides using 1,3-dibromo-5,5-dimethylhydantoin (DBDMH) as oxidant under both solution and solvent-free conditions.
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Details
The use of DBDMH provides a remarkably simple, mild, very rapid, selective, general and practical procedure for the high-yielding preparation of a variety of disulfides.
DBDMH is an excellent, cheap and conveniently handled reagent, so it is better than NBS for the oxidation of organic compounds.
Key Words
1,3-dibromo-5,5-dimethylhydantoin, oxidation, thiols, disulfides
ID: J66-Y2004-2410
