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Microwave-Assisted, Solvent-Free Bischler Indole Synthesis

Vellaisamy Sridharan, Subbu Perumal, Carmen Avendaño, J. Carlos Menéndez*

*Departamento de Química Orgánica y Farmacéutica, Facultad de Farmacia, Universidad Complutense, 28040 Madrid, Spain, Email:

V. Sridharan, S. Perumal, C. Avendaño, J. C. Menéndez, Synlett, 2006, 91-95.

DOI: 10.1055/s-2005-922760


The solid-state reaction between anilines and phenacyl bromides in the presence of an equimolecular amount of sodium bicarbonate or a second equivalent of the aniline followod by microwave irradiation provides a mild, general, and environmentally friendly method for the synthesis of 2-arylindoles in good overall yields.

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Key Words

indole synthesis, aniline monoalkylation, solvent-free synthesis, microwave-assisted synthesis, Bischler-Moehlau indole synthesis

ID: J60-Y2006-4180