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Δ3-Aryl/heteroaryl substituted heterocycles via sequential Pd-catalysed termolecular cascade/ring closing metathesis (RCM)

H. Ali Dondas, Blandine Clique, Bekir Cetinkaya, Ronald Grigg*, Colin Kilner, James Morris and Visuvanathar Sridharan

*Molecular Innovation, Diversity and Automated Synthesis (MIDAS) Centre, School of Chemistry, Leeds University, Leeds LS2 9JT, UK, Email:

H. A. Dondas, B. Clique, B. Cetinkaya, R. Grigg, C. Kilner, J. Morris, V. Sridharan, Tetrahedron, 2005, 61, 10652-10666.

DOI: 10.1016/j.tet.2005.08.078

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A Pd-catalysed termolecular allenylation cascade followed by a Ru catalysed RCM process affords a diverse range of Δ3-aryl/heteroaryl substituted five-seven membered nitrogen and oxygen heterocycles.

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Key Words

Ruthenium, Allenes, Allic Amines, Allylic Ethers, Multicomponent Reactions, Ring Closing Metathesis, 3-Pyrrolines, N-Heterocycles, O-Heterocycles

ID: J72-Y2005-3130