Practical Oppenauer (OPP) Oxidation of Alcohols with a Modified Aluminium Catalyst
Takashi Ooi, Hidehito Otsuka, Tomoya Miura, Hayato Ichikawa and Keiji Maruoka*
*Department of Chemistry, Graduate School of Science, Kyoto University,
Sakyo, Kyoto 606-8502, Email: maruoka
kuchem.kyoto-u.ac.jp
T. Ooi, H. Otshuka, T. Miura, H. Ichikawa, K. Maruoka, Org. Lett., 2002, 4, 2669-2672.
DOI: 10.1021/ol020094c
Abstract
An effective protocol for Oppenauer (OOP) oxidation of alcohols under mild conditions with t-BuCHO as hydride acceptor was developed. The highly active aluminium catalyst allowed even the oxidation of terpenoids and stereoids with acetone as the hydride acceptor.
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Key Words
Oppenauer Oxidation, Meerwein-Ponndorf-Verley Reduction, Pivaldehyde, Acetone
ID: J54-Y2002-500
