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An Air-Stable Palladium/N-Heterocyclic Carbene Complex and Its Reactivity in Aryl Amination

Mihai S. Viciu, Rebecca M. Kissling, Edwin D. Stevens and Steven P. Nolan*

*School of Chemistry, University of St Andrews, St Andrews KY16 9ST, U.K., Email: sn17st-andrews.ac.uk

M. S. Viciu, R. M. Kissling, E. D. Stevens, S. P. Nolan, Org. Lett., 2002, 4, 2229-2231.

DOI: 10.1021/ol0260831


Abstract

A mild and efficient amination of aryl chlorides and bromides could be performed under nitrogen and under aerobic conditions with small effects on yields and reaction times using the air and moisture stable complex [Pd(IPr)Cl2]2 as catalyst and potassium tert-amylate as base.

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Key Words

Buchwald-Hartwig Coupling


ID: J54-Y2002-530