An Amino Alcohol Ligand for Highly Enantioselecitve Addition of Organozinc Reagents to Aldehydes: Serendipity Rules

William A. Nugent*

*Bristol-Myers Squibb Company, Process and Research Department, Chambers Works, P.O. Box 269, Deepwater, New Jersey 08023-0269, Email: william.nugentbms.com

W. A. Nugent, Org. Lett., 2002, 4, 2133-2136.

DOI: 10.1021/ol0259488

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Abstract

(1S,2R)-2-(N-Morpholino)-1,2-dicyclohexylethanol promotes the enantioselective addition of diethylzinc to aldehydes in high enantiomeric excess.

see article for more examples

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Key Words

1,2-addition

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ID: J54-Y2002-540