Organic Chemistry Portal



Palladium-Catalyzed Cross-Coupling Reaction of Aryltriethoxysilanes with Aryl Bromides under Basic Aqueous Conditions

Miki Murata*, Ryuta Shimazaki, Shinji Watanabe and Yuzuru Masuda

*Department of Materials Science, Kitami Institute of Technology, Kitami 090-8507, Japan, Email:

M. Murata, R. Shimazaki, S. Watanabe, Y. Masuda, Synthesis, 2001, 2231-2233.

DOI: 10.1055/s-2001-18435


Aryltriethoxysilanes were cross-coupled with aryl bromides in high yield in the presence of a palladium catalyst and aqueous sodium hydroxide. Addition of P(OiPr)3 helps to prevent the precipitation of palladium black.

see article for more examples

Rhodium(I)-Catalyzed Silylation of Aryl Halides with Triethoxysilane: Practical Synthetic Route to Aryltriethoxysilanes

M. Murata, M. Ishikura, M. Nagata, S. Watanabe, Y. Masuda, Org. Lett., 2002, 4, 1843-1845.

Key Words

siloxane derivatives, cross-coupling, palladium catalyst, aryl bromides, biaryls, Hiyama Coupling

ID: J66-Y2001-170