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The Urea-Hydrogen Peroxide Complex: Solid-State Oxidative Protocols for Hydroxylated Aldehydes and Ketones (Dakin Reaction), Nitriles, Sulfides, and Nitrogen Heterocycles

Rajender S. Varma* and Kannan P. Naicker

*Clean Processes Branch, Sustainable Technology Division, National Risk Management Research Laboratory, U.S. Environmental Protection Agency, 26 West Martin Luther King Drive, MS 443, Cincinnati, Ohio 45268, Email:

R. S. Varma, K. P. Naicker, Org. Lett., 1999, 1, 189-191.

DOI: 10.1021/ol990522n

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Urea-hydrogen peroxide adduct (UHP) is stable, inexpensive and an easily handled reagent. UHP is used in an efficient solid state oxidation of different organic molecules: hydroxylated aldehydes and ketones (to hydroxylated phenols), sulfides (to sulfoxides and sulfones), nitriles (to amides) and nitrogen heterocycles (to N-oxides).

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Key Words

solvent-free, Dakin Reaction, UHP, Sulfoxides, Sulfones, N-Oxides

ID: J54-Y1999-110