The Urea-Hydrogen Peroxide Complex: Solid-State Oxidative Protocols for Hydroxylated Aldehydes and Ketones (Dakin Reaction), Nitriles, Sulfides, and Nitrogen Heterocycles
Rajender S. Varma* and Kannan P. Naicker
*Clean Processes Branch, Sustainable Technology Division, National Risk
Management Research Laboratory, U.S. Environmental Protection Agency, 26 West
Martin Luther King Drive, MS 443, Cincinnati, Ohio 45268,
Email: varma.rajender
epa.gov
R. S. Varma, K. P. Naicker, Org. Lett., 1999, 1, 189-191.
DOI: 10.1021/ol990522n
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Abstract
Urea-hydrogen peroxide adduct (UHP) is stable, inexpensive and an easily handled reagent. UHP is used in an efficient solid state oxidation of different organic molecules: hydroxylated aldehydes and ketones (to hydroxylated phenols), sulfides (to sulfoxides and sulfones), nitriles (to amides) and nitrogen heterocycles (to N-oxides).
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Key Words
solvent-free, Dakin Reaction, UHP, Sulfoxides, Sulfones, N-Oxides
ID: J54-Y1999-110
