A Brønsted Acid and Lewis Base Organocatalyst for the Aza-Morita-Baylis-Hillman Reaction
Katsuya Matsui, Shinobu Takizawa, Hiroaki Sasai*
*The Institute of Scientific and Industrial Research (ISIR), Osaka
University, Mihogaoka, Ibaraki, Osaka 567-0047, Japan, Email: sasai
sanken.osaka-u.ac.jp
K. Matsui, S. Takizawa, H. Sasai, Synlett, 2006, 761-765.
DOI: 10.1055/s-2006-933112
Abstract
(S)-3-[2-(Diphenylphosphino)phenyl]BINOL is an efficient asymmetric bifunctional organocatalyst for the aza-Morita-Baylis-Hillman reaction. The Brønsted acid and Lewis base functionalities cooperate in substrate activation to promote the reaction with high enantiocontrol.
see article for more examples
Bifunctional Organocatalysts for Enantioselective aza-Morita-Baylis-Hillman Reaction
K. Matsui, S. Takizawa, H. Sasai, J. Am. Chem. Soc., 2005, 127, 3680-3681.
Key Words
enantioselective aza-Morita-Baylis-Hillman reaction, bifunctional catalyst, Brønsted acid, Lewis base, organocatalysis, allylic amines
ID: J60-Y2006-4320
