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Copper-Catalyzed Coupling of Iodides with Aliphatic Alcohols

Martina Wolter, Gero Nordmann, Gabriel E. Job and Stephen L. Buchwald

*Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139

M. Wolter, G. Nordmann, G. E. Job, S. L. Buchwald, Org. Lett., 2002, 4, 973-976.

DOI: 10.1021/ol025548k


Abstract

A simple and mild coupling method of aryl iodides and aliphatic alcohols, which does not require alkoxide bases, can be performed in neat alcohol or toluene as solvent. An optically active benzylic alcohol underwent the reaction with complete retention of configuration.

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Key Words

Ullmann Ether Synthesis, Aryl Ethers


ID: J54-Y2002-620