Thiourea-Catalyzed Direct Reductive Amination of Aldehydes
Dirk Menche*, Fatih Arikan
*Gesellschaft für Biotechnologische Forschung mbH, Medzinische Chemie,
Mascheroder Weg 1, D-38124 Braunschweig, Germany, Email: dme05
gbf.de
D. Menche, F. Arikan, Synlett, 2006, 841-844.
Abstract
A hydrogen-bond-catalyzed, acid- and metal-free direct reductive amination of aldehydes uses thiourea as organocatalyst and the Hantzsch ester for transfer-hydrogenation. This methods allows for the high-yielding synthesis of diverse amines.
see article for more examples
Hydrogen Bond Catalyzed Direct Reductive Amination of Ketones
D. Menche, J. Hassfeld, J. Li, G. Menche, A. Ritter, S. Rudolph, Org. Lett., 2006, 8, 741-744.
Key Words
amines, reductive amination, organocatalysis, hydrogen bonds, Hantzsch ester
ID: J60-Y2006-4340
