Thiourea-Catalyzed Direct Reductive Amination of Aldehydes
Dirk Menche*, Fatih Arikan
*Gesellschaft für Biotechnologische Forschung mbH, Medzinische Chemie,
Mascheroder Weg 1, D-38124 Braunschweig, Germany, Email: dme05
gbf.de
D. Menche, F. Arikan, Synlett, 2006, 841-844.
DOI: 10.1055/s-2006-939052
Abstract
A hydrogen-bond-catalyzed, acid- and metal-free direct reductive amination of aldehydes uses thiourea as organocatalyst and the Hantzsch ester for transfer-hydrogenation. This methods allows for the high-yielding synthesis of diverse amines.
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Hydrogen Bond Catalyzed Direct Reductive Amination of Ketones
D. Menche, J. Hassfeld, J. Li, G. Menche, A. Ritter, S. Rudolph, Org. Lett., 2006, 8, 741-744.
Key Words
amines, reductive amination, organocatalysis, hydrogen bonds, Hantzsch ester
ID: J60-Y2006-4340
