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Thiourea-Catalyzed Direct Reductive Amination of Aldehydes

Dirk Menche*, Fatih Arikan

*Gesellschaft für Biotechnologische Forschung mbH, Medzinische Chemie, Mascheroder Weg 1, D-38124 Braunschweig, Germany, Email:

D. Menche, F. Arikan, Synlett, 2006, 841-844.

DOI: 10.1055/s-2006-939052


A hydrogen-bond-catalyzed, acid- and metal-free direct reductive amination of aldehydes uses thiourea as organocatalyst and the Hantzsch ester for transfer-hydrogenation. This methods allows for the high-yielding synthesis of diverse amines.

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Hydrogen Bond Catalyzed Direct Reductive Amination of Ketones

D. Menche, J. Hassfeld, J. Li, G. Menche, A. Ritter, S. Rudolph, Org. Lett., 2006, 8, 741-744.

Key Words

amines, reductive amination, organocatalysis, hydrogen bonds, Hantzsch ester

ID: J60-Y2006-4340