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A New Synthesis of Aldehydes by the Palladium-Catalyzed Reaction of 2-Pyridinyl Esters with Hydrosilanes

Jun Nakanishi, Hiroto Tatamidani, Yoshiya Fukumoto, Naoto Chatani*

*Department of Applied Chemistry, Faculty of Engineering, Osaka University, Suita, Osaka 565-0871, Japan, Email:

J. Nakanishi, H. Tatamidani, Y. Fukumoto, N. Chatani, Synlett, 2006, 869-872.

DOI: 10.1055/s-2006-939058


A palladium-catalyzed reduction of 2-pyridinyl esters using hydrosilanes is applicable to the preparation of aliphatic, aromatic, and α,β-unsaturated aldehydes. Various functional groups, such as fluoro, methoxy, aldehyde, acetal, and ester, are tolerated.

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Key Words

catalysis, 2-pyridinyl esters, triethylsilane, aldehydes, palladium

ID: J60-Y2006-4350