N-Iodosuccinimide (NIS) as a mild and highly chemoselective catalyst for deprotection of tert-butyldimethylsilyl ethers
Babak Karimi, Asghar Zamani and Daryoush Zareyee
*Department of Chemistry, Institute for Advanced Studies in Basic Sciences (IASBS),
PO Box 45195-159, Gava Zang, Zanjan, Iran, Email: karimi
iasbs.ac.ir
B. Karimi, A. Zamani, D. Zarayee, Tetrahedron Lett., 2004, 45, 9139-9141.
DOI: 10.1016/j.tetlet.2004.09.157
Abstract
Various tert-butyldimethylsilyl ethers are easily removed in excellent yields by treatment with a catalytic amount of N-iodosuccinimide in methanol. This method allows a selective deprotection of TBDMS ethers of alcohols in the presence of TBDMS ethers of phenols.
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Key Words
Silyl ethers, Deprotection, N-Iodosuccinimide, TBDMS ethers, Protecting groups
ID: J72-Y2004-2430
