N-Iodosuccinimide (NIS) as a mild and highly chemoselective catalyst for deprotection of tert-butyldimethylsilyl ethers
Babak Karimi, Asghar Zamani and Daryoush Zareyee
*Department of Chemistry, Institute for Advanced Studies in Basic Sciences (IASBS), PO Box 45195-159, Gava Zang, Zanjan, Iran, Email: karimiiasbs.ac.ir
B. Karimi, A. Zamani, D. Zarayee, Tetrahedron Lett., 2004, 45, 9139-9141.
Various tert-butyldimethylsilyl ethers are easily removed in excellent yields by treatment with a catalytic amount of N-iodosuccinimide in methanol. This method allows a selective deprotection of TBDMS ethers of alcohols in the presence of TBDMS ethers of phenols.
see article for more examples
Silyl ethers, Deprotection, N-Iodosuccinimide, TBDMS ethers, Protecting groups