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A Mild and Efficient Desilylation of O-tert-Butyldimethylsilyl Ethers Mediated by Chlorotrimethylsilane and Potassium Fluoride Dihydrate in Acetonitrile

Yu Peng, Wei-Dong Z. Li*

*State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P. R. of China, Email:

Y. Peng, W.-D. Z. Li, Synlett, 2006, 1165-1168.

DOI: 10.1055/s-2006-932474

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A chemoselective, efficient and operationally simple desilylation of O-tert-butyldimethylsilyl ethers was achieved using chlorotrimethylsilane and potassium fluoride dihydrate in acetonitrile.

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Key Words

desilylation, potassium fluoride, chlorotrimethylsilane, O-tert-butyldimethylsilyl ether

ID: J60-Y2006-4370