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Highly Enantioselective Hydrogenation of α-Keto Esters Catalyzed by Ru-Tunephos Complexes

Chun-Jiang Wang, Xianfeng Sun, Xumu Zhang*

*Department of Chemistry, The Pennsylvania State University, University Park, PA 16802, USA, Email: xumuchem.psu.edu

C.-J. Wang, X. Sun, X. Zhang, Synlett, 2006, 1169-1172.

DOI: 10.1055/s-2006-932461

Abstract

Various enantiomerically pure α-hydroxy esters were synthesized by a Ru-Cn-Tunephos-catalyzed asymmetric hydrogenation of α-keto esters. High enantiomeric excess has been achieved for both α-aryl and α-alkyl substituted α-keto esters.

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Key Words

asymmetric catalysis, enantioselectivity, ruthenium, hydrogenation, hydrogen, α-keto esters, carbonyl compounds

ID: J60-Y2006-4380