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N-Bromosuccinimide and Lithium Bromide: An Efficient Combination for the Dibromination of Carbon-Carbon Unsaturated Bonds

Li-Xiong Shao, Min Shi*

*State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, P. R. of China, Email:

L.-X. Shao, M. Shi, Synlett, 2006, 1269-1271.

DOI: 10.1055/s-2006-941558

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Unsaturated compounds such as alkenes, alkynes, allenes, and methylenecyclopropanes (MCPs) can be dibrominated within minutes by NBS and lithium bromide in THF at room temperature in good to excellent yields under mild conditions.

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Key Words

NBS, lithium bromide, unsaturated compounds, dibromination reaction, dibromoalkanes, dibromoalkenes, bromoalkenes, bromoalkanes

ID: J60-Y2006-4400