A Mild and Facile Method for Complete Hydrogenation of Aromatic Nuclei in Water
Tomohiro Maegawa, Akira Akashi, Hironao Sajiki*
*Laboratory of Medicinal Chemistry, Gifu Pharmaceutical University, Gifu 502-8585, Japan, Email: sajikigifu-pu.ac.jp
T. Maegawa, A. Akashi, H. Sajiki, Synlett, 2006, 1440-1442.
see article for more examples
A mild, complete hydrogenation of aromatic rings catalyzed by heterogeneous 10% Rh/C proceeds at 80 °C in water under 5 atm of H2 pressure and is applicable to the hydrogenation of various carbon and heteroaromatic compounds such as alkylbenzenes, biphenyls, pyridines and furans.