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A Convenient Synthesis of Oxazolines and Imidazolines from Aromatic Aldehydes with Pyridinium Hydrobromide Perbromide in Water

Shinsei Sayama*

*Department of Chemistry, Fukushima Medical University, Hikariga-oka, Fukushima 960-1295, Japan, Email:

S. Sayama, Synlett, 2006, 1479-1484.

DOI: 10.1055/s-2006-941597


Various 2-oxazolines were prepared from aromatic aldehydes and 2-aminoethanol with pyridinium hydrobromide perbromide in water at room temperature. The reaction of aromatic aldehydes with ethylenediamine gave 2-imidazolines in good yields under the same reaction conditions.

Key Words

oxazolines, imidazolines, pyridinium hydrobromide perbromide, aldehydes, 2-aminoethanol, ethylenediamine

ID: J60-Y2006-4440