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Revisiting the Passerini Reaction under Eco-Friendly Reaction Conditions

Carlos Kleber Z. Andrade*, Sayuri Cristina S. Takada, Paulo Anselmo Z. Suarez, Melquizedeque B. Alves

*Laboratório de Química Metodológica e Orgânica Sintética (LaQMOS), Instituto de Química, Universidade de Brasília, C.P. 4478, 70910-970, Brasília, DF, Brazil, Email:

C. K. Z. Andrade, S. C. S. Takada, P. A. Z. Suarez, M. B. Alves, Synlett, 2006, 1539-1541.

DOI: 10.1055/s-2006-941606


α-Acyloxy carboxamides were easily obtained in one step by a Passerini reaction between carboxylic acids, aldehydes and isocyanides in ionic liquids or polyethyleneglycol as green reaction media.

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Key Words

Passerini reaction, ionic liquids, multicomponent reactions, polyethylene glycol, green chemistry

ID: J60-Y2006-4470