Ceric Ammonium Nitrate Catalyzed aza-Michael Addition of Aliphatic Amines to α,β-Unsaturated Carbonyl Compounds and Nitriles in Water
Ravi Varala, Nuvula Sreelatha, Srinivas R. Adapa*
*Indian Institute of Chemical Technology, Hyderabad-500 007, India, Email: rvarala_iictyahoo.co.in
R. Varala, N. Sreelatha, S. R. Adapa, Synlett, 2006, 1549-1553.
Ceric ammonium nitrate efficiently catalyzes the aza-Michael reaction of amines with α,β-unsaturated carbonyl compounds in water to produce the corresponding β-amino carbonyl compounds in very good yields under mild conditions. The reaction is procedurally simple and offers limited chemoselectivity, as aromatic amines were found to be unreactive.
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