Ceric Ammonium Nitrate Catalyzed aza-Michael Addition of Aliphatic Amines to α,β-Unsaturated Carbonyl Compounds and Nitriles in Water
Ravi Varala, Nuvula Sreelatha, Srinivas R. Adapa*
*Indian Institute of Chemical Technology, Hyderabad-500 007, India, Email:
rvarala_iict
yahoo.co.in
R. Varala, N. Sreelatha, S. R. Adapa, Synlett, 2006, 1549-1553.
DOI: 10.1055/s-2006-941588
Abstract
Ceric ammonium nitrate efficiently catalyzes the aza-Michael reaction of amines with α,β-unsaturated carbonyl compounds in water to produce the corresponding β-amino carbonyl compounds in very good yields under mild conditions. The reaction is procedurally simple and offers limited chemoselectivity, as aromatic amines were found to be unreactive.
see article for more examples
Key Words
ceric ammonium nitrate, aza-Michael reaction, conjugate addition, aliphatic amines, α,β-unsaturated carbonyl compounds
ID: J60-Y2006-4480
