Organic Chemistry Portal



Ceric Ammonium Nitrate Catalyzed aza-Michael Addition of Aliphatic Amines to α,β-Unsaturated Carbonyl Compounds and Nitriles in Water

Ravi Varala, Nuvula Sreelatha, Srinivas R. Adapa*

*Indian Institute of Chemical Technology, Hyderabad-500 007, India, Email:

R. Varala, N. Sreelatha, S. R. Adapa, Synlett, 2006, 1549-1553.

DOI: 10.1055/s-2006-941588


Ceric ammonium nitrate efficiently catalyzes the aza-Michael reaction of amines with α,β-unsaturated carbonyl compounds in water to produce the corresponding β-amino carbonyl compounds in very good yields under mild conditions. The reaction is procedurally simple and offers limited chemoselectivity, as aromatic amines were found to be unreactive.

see article for more examples

Key Words

ceric ammonium nitrate, aza-Michael reaction, conjugate addition, aliphatic amines, α,β-unsaturated carbonyl compounds

ID: J60-Y2006-4480