The Kulinkovich Reaction on Lactones. A Convenient Approach to Functionalized Cyclopropanols
Annamaria Esposito and Maurizio Taddei*
*Dipartimento Farmaco Chimico Tecnologico, Polo Scientifico San Miniato, Via
Aldo Moro 2, 53100 Siena, Italy, Email: taddei.m
unisi.it
A. Esposito, M. Taddei, J. Org. Chem., 2000, 65, 9245-9248.
DOI: 10.1021/jo0011944
Abstract
The Kulinkovich reaction can be carried out successfully on lactones or THP-protected hydroxy esters to give cyclopropyl diols.
see article for more examples
comparison of the proposed mechanism of the Kulinkovich reaction on esters with a possible mechanism on lactones
Key Words
Kulinkovich Reaction, Cyclopronanols
ID: J42-Y2000-630
