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The Kulinkovich Reaction on Lactones. A Convenient Approach to Functionalized Cyclopropanols

Annamaria Esposito and Maurizio Taddei*

*Dipartimento Farmaco Chimico Tecnologico, Polo Scientifico San Miniato, Via Aldo Moro 2, 53100 Siena, Italy, Email:

A. Esposito, M. Taddei, J. Org. Chem., 2000, 65, 9245-9248.

DOI: 10.1021/jo0011944


The Kulinkovich reaction can be carried out successfully on lactones or THP-protected hydroxy esters to give cyclopropyl diols.

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comparison of the proposed mechanism of the Kulinkovich reaction on esters with a possible mechanism on lactones

Key Words

Kulinkovich Reaction, Cyclopronanols

ID: J42-Y2000-630