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Synthesis of Thiophene Derivatives on Soluble Polymer-Support Using Gewald Reaction

Haiqing Zhang, Guichun Yang*, Jianian Chen, Zuxing Chen

*Faculty of Chemistry and Material Science, Hubei University, Wuhan, Hubei, 430062, P. R. China, Email:

H. Zhang, G. Yang, J. Chen, Z. Chen, Synlett, 2004, 3055-3059.

DOI: 10.1055/s-2004-834895


The Gewald reaction of PEG-bound cyanoacetic ester, elemental sulfur, DIPEA and carbonyl compounds carried out under microwave irradiation afforded PEG-supported thiophenes, which were acylated and treated with 1% KCN in methanol to give free thiophenes in good yields. This synthetic method is simple and mild.

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Key Words

thiophene derivatives, synthesis, Gewald reaction, soluble polymer-support, microwave synthesis

ID: J60-Y2004-2450