Synthesis of Thiophene Derivatives on Soluble Polymer-Support Using Gewald Reaction
Haiqing Zhang, Guichun Yang*, Jianian Chen, Zuxing Chen
*Faculty of Chemistry and Material Science, Hubei University, Wuhan, Hubei,
430062, P. R. China, Email: ygc33
tom.com
H. Zhang, G. Yang, J. Chen, Z. Chen, Synlett, 2004, 3055-3059.
DOI: 10.1055/s-2004-834895
Abstract
The Gewald reaction of PEG-bound cyanoacetic ester, elemental sulfur, DIPEA and carbonyl compounds carried out under microwave irradiation afforded PEG-supported thiophenes, which were acylated and treated with 1% KCN in methanol to give free thiophenes in good yields. This synthetic method is simple and mild.
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Key Words
thiophene derivatives, synthesis, Gewald reaction, soluble polymer-support, microwave synthesis
ID: J60-Y2004-2450
