Iodine as an Efficient Catalyst for One-Pot Multicomponent Synthesis of β-Acetamido Ketones
Biswanath Das*, K. Ravinder Reddy, R. Ramu, P. Thirupathi, B. Ravikanth
*Organic Chemistry Division I, Indian Institute of Chemical Technology,
Hyderabad - 500 007, India, Email: biswanathdas
yahoo.com
B. Das, K. Ravinder Reddy, R. Ramu, P. Thirupathi, B. Ravikanth, Synlett, 2006, 1756-1758.
Abstract
Iodine efficiently catalyzes the three-component coupling of aromatic aldehydes, enolizable ketones or keto esters, and acetonitrile in the presence of acetyl chloride at room temperature to afford β-acetamido ketones in good yields.
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Key Words
β-acetamido ketones, iodine, multicomponent reactions
ID: J60-Y2006-4510
