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Iodine as an Efficient Catalyst for One-Pot Multicomponent Synthesis of β-Acetamido Ketones

Biswanath Das*, K. Ravinder Reddy, R. Ramu, P. Thirupathi, B. Ravikanth

*Organic Chemistry Division I, Indian Institute of Chemical Technology, Hyderabad - 500 007, India, Email:

B. Das, K. Ravinder Reddy, R. Ramu, P. Thirupathi, B. Ravikanth, Synlett, 2006, 1756-1758.

DOI: 10.1055/s-2006-944208


Iodine efficiently catalyzes the three-component coupling of aromatic aldehydes, enolizable ketones or keto esters, and acetonitrile in the presence of acetyl chloride at room temperature to afford β-acetamido ketones in good yields.

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Key Words

β-acetamido ketones, iodine, multicomponent reactions

ID: J60-Y2006-4510