A Novel, One-Pot, Three-Component Synthesis of 1,2,4-Oxadiazoles under Microwave Irradiation and Solvent-Free Conditions
Mehdi Adib*, Mohammad Mahdavi, Niusha Mahmoodi, Hooshang Pirelahi, Hamid Reza Bijanzadeh
*School of Chemistry, University College of Science, University of Tehran, Tehran, Iran, Email: madibkhayam.ut.ac.ir
M. Adib, M. Mahdavi, N. Mahmoodi, H. Pirelahi, H. R. Bijanzadeh, Synlett, 2006, 1765-1767.
A one-pot reaction between nitriles, hydroxylamine and Meldrum's acids under microwave irradiation and solvent-free conditions gives 3,5-disubstituted 1,2,4-oxadiazoles in good to excellent yields.
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