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A Novel, One-Pot, Three-Component Synthesis of 1,2,4-Oxadiazoles under Microwave Irradiation and Solvent-Free Conditions

Mehdi Adib*, Mohammad Mahdavi, Niusha Mahmoodi, Hooshang Pirelahi, Hamid Reza Bijanzadeh

*School of Chemistry, University College of Science, University of Tehran, Tehran, Iran, Email:

M. Adib, M. Mahdavi, N. Mahmoodi, H. Pirelahi, H. R. Bijanzadeh, Synlett, 2006, 1765-1767.

DOI: 10.1055/s-2006-944200


A one-pot reaction between nitriles, hydroxylamine and Meldrum's acids under microwave irradiation and solvent-free conditions gives 3,5-disubstituted 1,2,4-oxadiazoles in good to excellent yields.

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proposed mechanism

Key Words

Meldrum's acids, nitriles, 1,2,4-oxadiazoles, solvent-free synthesis, microwave synthesis

ID: J60-Y2006-4550