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Regioselective Halogen-Metal Exchange Reaction of 3-Substituted 1,2-Dibromo Arenes: The Synthesis of 2-Substituted 5-Bromobenzoic Acids

Karsten Menzel*, Lisa Dimichele, Paul Mills, Doug E. Frantz, Todd D. Nelson, Michael H. Kress

*Merck Research Laboratories, Department of Process Research, 466 Devon Park Drive, Wayne, Pennsylvania 19087, USA, Email:

K. Menzel, L. Dimichele, P. Mills, D. E. Frantz, T. D. Nelson, M. H. Kress, Synlett, 2006, 1948-1952.

DOI: 10.1055/s-2006-947362


Regioselective halogen-metal exchange reactions using isopropylmagnesium chloride were carried out on 3-substituted 1,2-dibromo arenes.

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Key Words

1,2-dibromobenzene, Grignard reactions, substitutent effect, regioselectivity, carboxylic acids

ID: J60-Y2006-4560