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New and easy route to primary cyclopropylamines from nitriles

Philippe Bertus and Jan Szymoniak*

*Réactions Sélectives et Applications, CNRS and Université de Reims, 51687 Reims Cedex 2, France, Email:

P. Bertus, J. Szymoniak, Chem. Commun., 2001, 1792-1793.

DOI: 10.1039/b105293b


Starting from readily available substrates, a new synthesis of primary cyclopropylamines involves a cooperative Ti(II)- and Lewis acid-mediated coupling of alkanenitriles with Grignard reagents.

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proposed mechanism

A Direct Synthesis of 1-Aryl- and 1-Alkenylcyclopropylamines from Aryl and Alkenyl Nitriles

P. Bertus, J. Szymoniak, J. Org. Chem., 2003, 68, 7133-7136.

Key Words

Kulinkovich-Szymoniak Reaction, Cyclopropylamines, Alkylamines

ID: JXX-Y2001-640