Chemoselective Bromination of Active Methylene and Methyne Compounds by Potassium Bromide, Hydrochloric Acid and Hydrogen Peroxide
Masayuki Kirihara*, Shiho Ogawa, Takuya Noguchi, Kumiko Okubo, Yoshinari Monma, Ikuko Shimizu, Ryuji Shimosaki, Akihiko Hatano, Yoshiro Hirai
*Department of Materials and Life Science, Shizuoka Institute of Science and
Technology, 2200-2 Toyosawa, Fukuroi, Shizuoka 437-8555, Japan, Email: kirihara
ms.sist.ac.jp
M. Kirihara, S. Ogawa, T. Noguchi, K. Okubo, Y. Monma, I. Shimizu, R. Shimosaki, A. Hatano, Y. Hirai, Synlett, 2006, 2287-2289.
Abstract
Active methylene compounds can be chemoselectively brominated in high yields using potassium bromide, hydrochloric acid, and hydrogen peroxide at room temperature.
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Key Words
halogenation, halides, green chemistry, bromination, active methylene compounds, hydrogen peroxide
ID: J60-Y2006-4610
