Organic Chemistry Portal



Efficient Demethylation of N,N-Dimethylanilines with Phenyl Chloroformate in Ionic Liquids

Satomi Imoria, Hideo Togo*

*Graduate School of Science and Technology, Chiba University, Yayoi-cho 1-33, Inage-ku 263-8522, Japan, Email:

S. Imoria, H. Togo, Synlett, 2006, 2629-2632.

DOI: 10.1055/s-2006-951490


Demethylation of N,N-dimethylanilines was carried out in various ionic liquids and acetonitrile as well as under solvent-free conditions. The reactivity dramatically depends on the employed solvent, with [bmim]Cl showing the best reactivity.

see article for more examples

Key Words

N,N-dimethylaniline, demethylation, phenyl chloroformate, ionic liquids, phenyl N-methyl-N-arylcarbamates, carbamates

ID: J60-Y2006-4680