A General and Mild Copper-Catalyzed Arylation of Diethyl Malonate
Edward J. Hennessy and Stephen L. Buchwald*
*Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, Email: sbuchwalmit.edu
E. J. Hennessy, S. L. Buchwald, Org. Lett., 2002, 4, 269-272.
DOI: 10.1021/ol017038g (free Supporting Information)
The coupling of aryl iodides and diethyl malonate in the presence of Cs2CO3 and catalytic amounts of CuI and 2-phenylphenol gave α-aryl malonates in good to excellent yields. This mild method tolerates various functional groups.
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required bidentate binding