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A Modified U-4CR Reaction with 2-Nitrobenzylamine as an Ammonia Equivalent

Kuangsen Sung*, Fu-Lin Chen, Pei-Chun Huang

*Department of Chemistry, National Cheng Kung University, Tainan, Taiwan, Email:

K. Sung, F.-L. Chen, P.-C. Huang, Synlett, 2006, 2667-2669.

DOI: 10.1055/s-2006-951485


2-Nitrobenzylamine can be used as an ammonia equivalent in a modified U-4CR multi-component reaction. A photochemical cleavage of the 2-nitrobenzyl group gives peptides in good yields, without isolation of the protected intermediates.

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Key Words

multicomponent reactions, Ugi reaction, photochemistry, peptides, isocyanides, ammonia equivalent

ID: J60-Y2006-4710