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Conjugate Reduction of α,β-Unsaturated Carbonyl Compounds Promoted by Nickel Nanoparticles

Francisco Alonso, Iñaki Osante, Miguel Yus*

*Departamento de Química Orgánica, Facultad de Ciencias and Instituto de Química Orgánica (ISO), Universidad de Alicante, Apdo 99, 03080 Alicante, Spain, Email:

F. Alonso, I. Osante, M. Yus, Synlett, 2006, 3017-3020.

DOI: 10.1055/s-2006-951494


A system composed of nickel(II) chloride, lithium metal, a catalytic polymer-supported arene, and ethanol, has been efficiently applied to the conjugate reduction of various α,β-unsaturated carbonyl compounds under very mild reaction conditions.

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Key Words

conjugate reduction, ketones, carboxylic acid derivatives, nickel, lithium, nanoparticles

ID: J60-Y2006-4750