Conjugate Reduction of α,β-Unsaturated Carbonyl Compounds Promoted by Nickel Nanoparticles
Francisco Alonso, Iñaki Osante, Miguel Yus*
*Departamento de Química Orgánica, Facultad de Ciencias and Instituto de
Química Orgánica (ISO), Universidad de Alicante, Apdo 99, 03080 Alicante, Spain, Email:
yus
ua.es
F. Alonso, I. Osante, M. Yus, Synlett, 2006, 3017-3020.
DOI: 10.1055/s-2006-951494
Abstract
A system composed of nickel(II) chloride, lithium metal, a catalytic polymer-supported arene, and ethanol, has been efficiently applied to the conjugate reduction of various α,β-unsaturated carbonyl compounds under very mild reaction conditions.
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Details
The authors described a new reducing system, based on the in situ generation of nickel(0) nanoparticles and molecular hydrogen, which has been successfully applied to the selective conjugate reduction of a,b-unsaturated ketones and carboxylic acid derivatives. Good to excellent yields of the products were obtained under very mild reaction conditions.
Key Words
conjugate reduction, ketones, carboxylic acid derivatives, nickel, lithium, nanoparticles
ID: J60-Y2006-4750
