A Convenient Protocol for the Synthesis of Hindered Aryl Malononitriles
Anita Schnyder*, Adriano F. Indolese, Thomas Maetzke, Jean Wenger, Hans-Ulrich Blaser
*Solvias AG, Postfach, 4002 Basel, Switzerland, Email: anita.schnydersolvias.com
A. Schnyder, A. F. Indolese, T. Maetzke, J. Wenger, H.-U. Blaser, Synlett, 2006, 3167-3168.
A convenient method has been developed for the palladium-catalyzed arylation of malononitrile in high yields with aryl bromides and chlorides, respectively. The influence of several reaction parameters such as base, ligand, solvent or temperature were investigated.
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arylation, aryl malononitriles, C-C coupling reaction, Pd catalysis, oxopyrazoline herbicide