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Organocatalysis of the Morita-Baylis-Hillman Alkylation Using Trialkylphosphines

Marie E. Krafft*, Kimberly A. Seibert

*Department of Chemistry and Biochemistry, Florida State University, Tallahassee, FL 32306-4390, USA, Email:

M. E. Krafft, K. A. Seibert, Synlett, 2006, 3334-3336.

DOI: 10.1055/s-2006-951531


Using a catalytic amount of trialkylphosphines, alkyl halides undergo efficient intramolecular Morita-Baylis-Hillman cyclization.

see article for more examples

Organomediated Morita-Baylis-Hillman Cyclization Reactions

M. E. Krafft, T. F. N. Haxell, J. Am. Chem. Soc., 2005, 127, 10168-10169.

Key Words

Baylis-Hillman Reaction, Organocatalysis, Cyclopentenes, Cyclohexenes, Enones

ID: J60-Y2006-4810