Organic Chemistry Portal



Nitroaldol Reaction in Aqueous Media: An Important Improvement of the Henry Reaction

Roberto Ballini* and Giovanna Bosica

*Dipartimento di Scienze Chimiche dell'UniversitÓ, Via S. Agostino n. 1, 62032 Camerino, Italy, Email:

R. Ballini, G. Bosica, J. Org. Chem., 1997, 62, 425-427.

DOI: 10.1021/jo961201h


The Henry reaction can be performed under very mild reaction conditions in 0.025 M NaOH in the presence of cetyltrimethylammonium chloride as cationic surfactant. Short reaction times are required and both primary and secondary nitroalkanes give good results.

see article for more examples

Key Words

Henry Reaktion, Henry Nitroaldol Reaction, Nitro compounds

ID: J42-Y1997-160