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Transition-Metal-Free Suzuki-Type Coupling Reactions

Nicholas E. Leadbeater*, Maria Marco

*Department of Chemistry, University of Connecticut, Unit 3060, 55 North Eagleville Road, Storrs, Connecticut 06269-3060, Email: nicholas.leadbeateruconn.edu

N. E. Leadbeater, M. Marco, Angew. Chem. Int. Ed., 2003, 42, 1407-1409.

DOI: 10.1002/anie.200390362


A Reassessment of the Transition-Metal Free Suzuki-Type Coupling Methodology

R. K. Arvela, N. E. Leadbeater, M. S. Sangi, V. A. Williams, P. Granados, R. D. Singer, J. Org. Chem. 2005, 70, 161-168.

DOI: 10.1021/jo048531j


Abstract

A microwave-assisted suzuki-type coupling of boronic acids and aryl halides in aqueous media is possible without the need for a transition-metal catalyst. Use of TBAB as an additive and the amount of base considerably affect the yield.

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Key Words

Suzuki Coupling, aqueous chemistry, biaryl compounds, boron, cross-coupling, microwave chemistry


ID: J06-Y2003-090