Transition-Metal-Free Suzuki-Type Coupling Reactions
Nicholas E. Leadbeater*, Maria Marco
*Department of Chemistry, University of Connecticut, Unit 3060, 55 North
Eagleville Road, Storrs, Connecticut 06269-3060, Email: nicholas.leadbeater
uconn.edu
N. E. Leadbeater, M. Marco, Angew. Chem. Int. Ed., 2003, 42, 1407-1409.
DOI: 10.1002/anie.200390362
A Reassessment of the Transition-Metal Free Suzuki-Type Coupling Methodology
R. K. Arvela, N. E. Leadbeater, M. S. Sangi, V. A. Williams, P. Granados, R. D. Singer, J. Org. Chem. 2005, 70, 161-168.
DOI: 10.1021/jo048531j
Abstract
A microwave-assisted suzuki-type coupling of boronic acids and aryl halides in aqueous media is possible without the need for a transition-metal catalyst. Use of TBAB as an additive and the amount of base considerably affect the yield.
see article for more examples
Key Words
Suzuki Coupling, aqueous chemistry, biaryl compounds, boron, cross-coupling, microwave chemistry
ID: J06-Y2003-090
