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Palladium-Catalyzed Cross-Coupling Reactions of 4-Tosyl-2(5H)-furanone with Boronic Acids: A Facile and Efficient Route to Generate 4-Substituted 2(5H)-Furanones

Jie Wu,* Qiang Zhu, Lisha Wang, Reza Fathi and Zhen Yang*

*VivoQuest, Inc., 711 Executive Blvd., Suite Q, Valley Cottage, New York 10989, Email:

J. Wu, Q. Zhu, L. Wang, R. Fathi, Z. Yang, J. Org. Chem., 2003, 68, 670-673.

DOI: 10.1021/jo020629f (free Supporting Information)


4-tosyl-2(5H)-furanone is easy to prepare in excellent yield and more stable than the corresponding triflate. A palladium catalyzed reaction between 4-tosyl-2(5H)-furanone and boronic acids gives 4-substituted 2(5H)-furanones.

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Key Words

Suzuki Coupling, Butenolides

ID: J42-Y2003-220