Novel Method for Incorporating the CHF₂ Group into Organic Molecules Using BrF₃

Revital Sasson, Aviv Hagooly and Shlomo Rozen*

*School of Chemistry, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel-Aviv University, Tel-Aviv 69978, Israel, Email: rozenspost.tau.ac.il

R. Sasson, A. Hagooly, S. Rozen, Org. Lett., 2003, 5, 3635-3641.

DOI: 10.1021/ol034051n

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Abstract

Easily prepared 2-alkyl-1,3-dithiane derivatives were reacted with BrF₃ to form the corresponding 1,1-difluoromethyl alkanes in good yield. The reaction proceeds well with primary alkyl halides. The limiting step for secondary alkyl halides is the relatively low yield of the dithiane preparation.

see article for more reactions

reactions of oxathioacetals and acetals

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Key Words

Dithianes, Difluoroalkanes

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ID: J54-Y2003-330