Novel Method for Incorporating the CHF2 Group into Organic Molecules Using BrF3
Revital Sasson, Aviv Hagooly and Shlomo Rozen*
*School of Chemistry, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel-Aviv University, Tel-Aviv 69978, Israel, Email: rozenspost.tau.ac.il
R. Sasson, A. Hagooly, S. Rozen, Org. Lett., 2003, 5, 3635-3641.
Easily prepared 2-alkyl-1,3-dithiane derivatives were reacted with BrF3 to form the corresponding 1,1-difluoromethyl alkanes in good yield. The reaction proceeds well with primary alkyl halides. The limiting step for secondary alkyl halides is the relatively low yield of the dithiane preparation.
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reactions of oxathioacetals and acetals