Transition Metal-Catalyzed Regio- and Stereoselective Aminobromination of Olefins with TsNH2 and NBS as Nitrogen and Bromine Sources
Vinay V. Thakur, Siva Kumar Talluri and A. Sudalai*
*Process Development Division, National Chemical Laboratory, Pashan Road, Pune-411 008, India, Email: a.sudalaincl.res.in
V. V. Thakur, S. K. Talluri, A. Sudalai, Org. Lett., 2003, 5, 861-864.
DOI: 10.1021/ol027530f (free Supporting Information)
A new procedure for aminobromination of olefins gives vicinal bromoamine derivatives in high yields using Cu, Mn, or V catalysts with p-toluenesulfonamide as nitrogen source and N-bromosuccinimide (NBS) as bromine source. Excellent regio- and stereoselectivity is shown for different olefinic substrates as well as transition metal catalysts.
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