Organic Chemistry Portal



In Situ Oxidation-Imine Formation-Reduction Routes from Alcohols to Amines

Leonie Blackburn and Richard J. K. Taylor*

*Department of Chemistry, University of York, Heslington, York, YO10 5DD, UK, Email:

L. Blackburn, R. J. K. Taylor, Org. Lett., 2001, 3, 1637-1639.

DOI: 10.1021/ol015819b

see article for more examples


Manganese dioxide is employed as an in situ oxidant for the one-pot conversion of alcohols into imines. In combination with polymer-supported cyanoborohydride (PSCBH), a one-pot oxidation-imine formation-reduction sequence enables alcohols to be converted directly into both secondary and tertiary amines.

see article for more examples

Key Words

Imines, Reduction of imines, Amination, Manganese(IV) oxide, Sodium borohydride, Sodium cyanoborohydride

ID: J54-Y2001-240