In Situ Oxidation-Imine Formation-Reduction Routes from Alcohols to Amines
Leonie Blackburn and Richard J. K. Taylor*
*Department of Chemistry, University of York, Heslington, York, YO10 5DD,
UK, Email: rjkt1
york.ac.uk
L. Blackburn, R. J. K. Taylor, Org. Lett., 2001, 3, 1637-1639.
DOI: 10.1021/ol015819b
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Abstract
Manganese dioxide is employed as an in situ oxidant for the one-pot conversion of alcohols into imines. In combination with polymer-supported cyanoborohydride (PSCBH), a one-pot oxidation-imine formation-reduction sequence enables alcohols to be converted directly into both secondary and tertiary amines.
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Key Words
Imines, Reduction of imines, Amination, Manganese(IV) oxide, Sodium borohydride, Sodium cyanoborohydride
ID: J54-Y2001-240
